Expression of osmotically responsive cationic channel TRPV4 in the endolymphatic sac
نویسندگان
چکیده
The immunohistochemical expression pattern and the physiological role of transient receptor potential vanilloid (TRPV) 4 in the endolymphatic sac were investigated. TRPV4 was expressed predominantly in the apical membrane of the mitochondria-rich cells and cell volume regulation by TRPV4 was observed in a tissue culture of the rat endolymphatic sac. TRPV4 was also present in the endolymphatic sac of both patients with vestibular schwannoma and with Meniere’s disease. TRPV4 is assumed to plays a role in cell and fluid volume regulation in the human endolymphatic sac as an osmoreceptor. Key word: Endolymphatic sac , Transient receptor potential vanilloid 4 , Meniere’s disease , Osmolarity
منابع مشابه
Expression of the osmotically responsive cationic channel TRPV4 in the endolymphatic sac.
The immunohistochemical expression pattern and the physiological role of transient receptor potential vanilloid (TRPV) 4 in the endolymphatic sac were investigated. TRPV4 was expressed predominantly in the apical membrane of mitochondria-rich cells, and cell volume regulation by TRPV4 was observed in a tissue culture of the rat endolymphatic sac. TRPV4 was also present in the endolymphatic sacs...
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